Shuo Tong（佟硕）

Doctor | Associate Professor | Doctoral Supervisor

Doctor | Associate Professor | Doctoral Supervisor

Tsinghua University
Department of Chemistry
Phone: 010-62797527
Fax: 010-6279-6761
Email: tongshuo@mail.tsinghua.edu.cn

  Shuo Tong was born in Jilin, China in March 1984. She obtained her BSc in chemistry in 2007 at Jilin University (China) and her PhD in 2013 from the Institute of Chemistry of the Chinese Academy of Sciences (ICCAS), Beijing, under the supervision of Professor Mei-Xiang Wang. She then joined Professor Jieping Zhu’s group at École Polytechnique Fédérale de Lausanne (EPFL) as a postdoctoral associate. After a 5-year research stay in Switzerland, she started her independent career as a Tenure-track principle investigator at Department of Chemistry at Tsinghua University in 2018. She is interested in catalytic enantioselective transformations, multicomponent reactions, macrocyclic and supramolecular chemistry. The research group is devoted to develop chiral supramolecular system of inherently chiral macrocyclic compounds. To achieve this goal, they are exploring methods to synthesize and assemble enantiopure inherently chiral macrocyclic compounds.

Education

2003-2007 B.Sc., Jilin University, Jilin, China

2007-2013 Ph.D., Institute of Chemistry Chinese Academy of Sciences, Beijing, China

Professional Experience

2013-2018 Postdoc École Polytechnique Fédérale de Lausanne (EPEL)
2018-present Tsinghua University

Research Interests

  1. Asymmetric synthesis of inherently chiral macrocyclic compounds
  2. Macrocyclic and supramolecular chemistry
  3. Chiroptical materials

Awards and Honors

  1. Thieme Chemistry Journals Award (2023)
  2. Honored with “Rising Star” in the 21st National Symposium on Macrocyclic Chemistry & the 13th Supramolecular Chemistry Symposium of CCS (2023)
  3. National Program for Thousand Young Talents (2018)
  4. “Best PhD Graduate”, Institute of Chemistry, Chinese Academy of Sciences (2013)

Invited Talks

  1. WISC Symposium – ISMSC 2024, Women in Supramolecular Chemistry Workshop, Hangzhou (05/05/2024)
  2. The 10th National Symposium on Molecular Chirality, Fuzhou (02/12/2023)
  3. Chem-Reaxys Symposium, Beijing (27/10/2023)
  4. The 21st National Symposium on Macrocyclic Chemistry & the 13th Supramolecular Chemistry Symposium of CCS, Tianjin (17/08/2023)
  5. The 1st Synthetic Chemistry Symposium of the Liupan Mountain Forum, Guyuan (07/08/2023)
  6. The 33rd annual conference of CCS, Qingdao (18/06/2023)
  7. The 12th National Conference on Organic Chemistry of CCS, Hefei (27/09/2022)

Publications

Independent Research

  1. Han, H.#; Wang, X.-G.#; Tong, S.*; Zhu, J.; Wang, M.-X. C4-Symmetric Inherently Chiral Macrocycles from Organocatalytic Enantioselective Desymmetrization of Resorcin[4]arenes. ACS Catal. 2025, 15, https://doi.org/10.1021/acscatal.5c00340.

  2. Ibragimova, R.#; Lu, Q.-L.#; Wang, M.-X.; Zhu, J.; Tong, S.* Asymmetric Synthesis of Inherently Chiral Tetraoxacalix[2]arene[2]pyridines via SNAr-based Cross-cyclotetramerization. Chem. Asian J. 2025, e202401621.

  3. Chen, J.-H.; Huang, T.-Y.; Tong, S.*; Wang, M.-X.* N-Doped Zigzag-Type Aromatic Truncated Cone Belts. J. Am. Chem. Soc. 2025, 147, 1595-1603.

  4. Jiang, Y.-F.; Tong, S.*; Zhu, J.; Wang, M.-X. Inherently Chiral Nor-Heteracalixarenes: Design and Synthesis via Enantioselective Intramolecular Suzuki-Miyaura Reaction. Chem. Sci. 2024, 15, 12517-12522.

  5. Lu, Q.-L.; Wang, X.-D.; Tong, S.*; Zhu, J.; Wang, M.-X. Catalytic Enantioselective Synthesis of Inherently Chiral Macrocycles by Dynamic Kinetic Resolution. ACS Catal. 2024, 14, 5140-5146.

  6. Wang, X.-Y.#; Zhang, X.-Y.#; Tong, S.*; Guo, Q.-H.; Tan, M.-L.; Li, C.-J.; Wang, M.-X.* Inherently Chiral and Symmetrical Heteroatom-Doped Zigzag-Type Hydrocarbon Belts. CCS Chem. 2024, 6, 1198-1210.

  7. Li, X.-C.; Cheng, Y.*; Wang, X.-D.; Tong, S.*; Wang, M.-X.* De Novo Synthesis of Inherently Chiral Heteracalix[4]aromatics from Enantioselective Macrocyclization Enabled by Chiral Phosphoric Acid-Catalyzed Intramolecular SNAr Reaction. Chem. Sci. 2024, 15, 3610-3615.

  8. Zhang, Y.; Cheng, Y.* Liang, D.-D.; Tong, S.; Wang, M.-X.* Synthesis of Inherently Chiral Homo-heteracalixaromatics. Org. Lett. 2024, 26, 7961-7965.

  9. Guo, S.-Y.; Zhang, Z.-A.; Tong, S.*; Guo, Q.-H.; Hua, R.; Wang, M.-X.* Tetrahomo Corona[4]arene-based Spirophanes: Synthesis, Structure, and Properties. Chem. Sci. 2023, 14, 8393-8400.

  10. Mao, Y.-Q.; Zhang, Y.; Tong, S.*; Zhu, J.; Wang, M.-X.* Asymmetric Synthesis of Enantioenriched Zigzag-type Molecular Belts by Kinetic Resolution and Subsequent Transformations. Org. Lett. 2023, 25, 3936-3940.

  11. Peng, Y.; Tong, S.*; Zhang, Y.; Wang, M.-X.* Functionalized Hydrocarbon Belts: Synthesis, Structure and Properties. Angew. Chem. Int. Ed. 2023, 62, e202302646.

  12. Chen, J.-H.; Jiang, Z.-Y.; Xiao, H.*; Tong, S.*; Shi, T.-H.; Zhu, J.; Wang, M.-X. Highly Strained Oxygen-doped Chiral Molecular Belts of Zigzag-type with Strong Circularly Polarized Luminescence. Angew. Chem. Int. Ed. 2023, 62, e202301782.

  13. Wang, F.; Zhang, Q.; Tong, S.*; Wang, M.-X.* Arene C–H Bond Trifluoromethylation Reactions Involving Different High Valent Arylcopper Intermediates. Sci. China Chem. 2023, 53, 522-528.

  14. Zhang, X.; Tong, S.*; Zhu, J.; Wang, M.-X. Inherently Chiral Calixarenes by a Catalytic Enantioselective Desymmetrizing Cross-Dehydrogenative Coupling. Chem. Sci. 2023, 14, 827-832.

  15. Feng, Q.-Y.; Tong, S.*; Vatsadze, Z. S.; Wang, M.-X. C1-symmetric Aza-crown Ethers as Chiral Shift Agents for Amines and Amino Acid Derivatives. Tetrahedron 2023, 131, 133207.

  16. Xie, M.; Tong, S.; Wang, M.-X.* Construction and Functionalization of Highly Strained N-Doped Zigzag Hydrocarbon Belts. CCS Chem. 2023, 5, 117-123.

  17. Guo, S.-Y.; Tong, S.; Guo, Q.-H.; Wang, M.-X.* Construction of Methylene-Bridged Electron-deficient Corona[n]arenes and Selective Fluoride Recognition Through Anion–π Interactions. Org. Chem. Front. 2023, 10, 1405-1411.

  18. Zhu, W.; Cheng, Y.*; Tong, S.; Wang, M.-X.* Synthesis of Functionalized ABAC- and ABCD-type Inherently Chiral Heteracalix[4]aromatics. Org. Lett. 2023, 25, 5105-5110.

  19. Feng, Q.-Y.; Mao, Y.-Q.; Wang, M.-X.; Tong, S.* Chiral Crown Ethers Accessed from Catalytic Enantioselective Desymmetrization Reactions. Org. Lett. 2022, 24, 7107-7112.

  20. Wang, W.; Tong, S.*; Wang, Q.-Q.; Ao, Y.-F.; Wang, D.-X.*; Zhu, J.* Thiazole Boron Difluoride Dyes with Large Stokes Shift, Solid State Emission and Room-Temperature Phosphorescence. Chem. Eur. J. 2022, 28, e202202507.

  21. Zhang, Q.; Tong, S.; Wang, M.-X.* Unraveling the Chemistry of High Valent Arylcopper Compounds and Their Roles in Copper-catalyzed Arene C-H Bond Transformations Using Synthetic Macrocycles. Acc. Chem. Res. 2022, 55, 2796-2810.

  22. Liang, D.-D.; Guo, S.-Y.; Tong, S.*; Wang, M.-X.* Polyfunctionalized Biaryls Accessed by a One-pot Nucleophilic Aromatic Substitution and Sigmatropic Rearrangement Reaction Cascade Under Mild Conditions. Tetrahedron 2021, 83, 131966.

  23. Tong, S.*; Wang, M.-X.* Domino Reactions of Tertiary Enamides in Organic Synthesis. Synlett 2021, 32, 1419-1427.

  24. Xie, M.; Tong, S.; Wang, M.-X.* Synthesis and Reactions of C4-symmetric 1,3,5,7(1,3)-tetrabenzenacyclooctaphane Tetraazide and Tetraamine Derivatives: Toward the Synthesis of Nitrogen-embedded Zigzag Hydrocarbon Belts. Org. Lett. 2021, 23, 1835-1839.

  25. Zhang, Y.-E.; Tong, S.; Wang, M.-X.* Selective Oxidation of Belt[4]arene[4]tropilidene and its Application to Construct Hydrocarbon Belts of Truncated Cone Structure with Expand Cavity. Org. Lett. 2021, 23, 7259-7263.

  26. Tong, S.*; Li, J.-T.; Liang, D.-D.; Zhang, Y.-E.; Feng, Q.-Y.; Zhang, X.; Zhu, J.; Wang, M.-X.* Catalytic Enantioselective Synthesis and Switchable Chiroptical Property of Inherently Chiral Macrocycles. J. Am. Chem. Soc. 2020, 142, 14432-14436.

  27. Tan, M.-L.; Tong, S.*; Hou, S.-K.; You, J.; Wang, M.-X.* Copper-catalyzed N,N-Diarylation of Amides for the Construction of 9,10-Dihydroacridine Structure and Applications in the Synthesis of Diverse Nitrogen-embedded Polyacenes. Org. Lett. 2020, 22, 5417-5422.

  28. Feng, Q.-Y.; Zhu, J.; Wang, M.-X.; Tong, S.* Organocatalytic Double Ugi Reaction with Statistical Amplification of Product Enantiopurity: A Linker Cleavage Approach to Access Highly Enantiopure Ugi Products. Org. Lett. 2020, 22, 483-487.

  29. Zhen, L.; Tong, S.*; Zhu, J.; Wang, M.-X.* Construction of the Erythrinane Core Skeleton via Asymmetric Catalytic Cascade Reaction of Tertiary Enamides. J. Org. Chem. 2020, 85, 13211-13219.

  30. Zhen, L.; Tong, S.*; Zhu, J.; Wang, M.-X.* Fused N-heterocycles with Contiguous Stereogenic Centers Accessed by an Asymmetric Catalytic Cascade Reaction of Tertiary Enamides. Chem. Eur. J. 2020, 26, 401-405.

  31. Zhang, Q.; Zhang, Y.-E.; Tong, S.; Wang, M.-X.* Hydrocarbon Belts with Truncated Cone Structures. J. Am. Chem. Soc. 2020, 142, 1196-1199.

  32. Guo, S.-Y.; Guo, Q.-H.; Tong, S.; Wang, M.-X.* Synthesis of Electron-deficient Corona[5]arenes and Their Selective Complexation with Dihydrogen Phosphate: Cooperative Effects of Anion-π Interactions. Angew. Chem. Int. Ed. 2020, 59, 8078-8083.

  33. Shi, T.-H.#; Guo, Q.-H.#; Tong, S.; Wang, M.-X.* Toward the Synthesis of a Highly Strained Hydrocarbon Belt. J. Am. Chem. Soc. 2020, 142, 4576-4580.

  34. Shi, T.-H.; Tong, S.; Wang, M.-X.* Construction of Hydrocarbon Nanobelts. Angew. Chem. Int. Ed. 2020, 59, 7700-7705.

  35. Zhang, Y.; Tong, S.; Wang, M.-X.* Synthesis and Structure of Functionalized Zigzag Hydrocarbon Belts. Angew. Chem. Int. Ed. 2020, 59, 18151-18155.

  36. Zhuang, S.-Y.; Cheng, Y.*; Zhang, Q.; Tong, S.; Wang, M.-X.* Synthesis of i-Corona[6]arenes for Selective Anion Binding: Interdependent and Synergistic Anion-π and Hydrogen Bond Interactions. Angew. Chem. Int. Ed. 2020, 59, 23716-23723.

  37. Tan, M.-L.#; Guo, Q.-H.#; Wang, X.-Y.; Shi, T.-H.; Zhang, Q.; Hou, S.-K.; Tong, S.; You, J.; Wang, M.-X.* Oxygen and Nitrogen-embedded Zigzag Hydrocarbon Belts. Angew. Chem. Int. Ed. 2020, 59, 23649-23658.

  38. Shi, T.-H.; Tong, S.; Jiao, L.*; Wang, M.-X.* A Theoretical Study on the Macrocyclic Strain of Zigzag Molecular Belts. Org. Mater. 2020, 2, 300-305.

  39. Tong, S.*; Wang, M.-X.* Catalytic Enantioselective Synthesis of 4-Amino-1,2,3,4-Tetrahydropyridine Derivatives from Intramolecular Nucleophilic Addition Reaction of Tertiary Enamides. Synlett 2019, 30, 483-487.

  40. Zhu, W.; Tong, S.*; Zhu, J.; Wang, M.-X.* Intramolecular Arylation of Tertiary Enamides Through Pd(OAc)2 Catalyzed Dehydrogenative Cross-coupling Reaction: Construction of Fused N-heterocyclic Scaffolds and Synthesis of Isoindolobenzazepine Alkaloids. J. Org. Chem. 2019, 84, 8270-8278.

  41. Zhang, Q.#; Wang, T.#; Zhang, X.*; Tong, S.; Wu, Y.-D.; Wang, M.-X.* Radical Reactivity, Catalysis, and Reaction Mechanism of Arylcopper(II) Compounds: the Missing Link in Organocopper Chemistry. J. Am. Chem. Soc. 2019, 141, 18341-18348.

  42. Xu, X.-M.#; Lei, C.-H.#; Tong, S.*; Zhu, J.; Wang, M.-X.* Lewis Acid Catalyst-steered Divergent Synthesis of Functionalized Vicinal Amino Alcohols and Pyrroles from Tertiary Enamides. Org. Chem. Front. 2018, 5, 3138-3142.

Publication during Ph.D. Study and Postdoctoral Research

  1. Tong, S.; Wang, D.-X.; Zhao, L.; Zhu, J.; Wang, M.-X.* Enantioselective Synthesis of 4-Hydroxytetrahydropyridine Derivatives by Intramolecular Addition of Tertiary Enamides to Aldehydes. Angew. Chem. Int. Ed. 2012, 51, 4417-4420.
  2. Tong, S.; Yang, X.; Wang, D.-X.; Zhao, L.; Zhu, J.; Wang, M.-X.* Synthesis of 4-Amino-1,2,3,4-tetrahydropyridine Derivatives by Intramolecular Nucleophilic Addition of Tertiary Enamides to in-situ Generated Imines. Tetrahedron, 2012, 68, 6492-6497.
  3. Tong, S.; Wang, Q.; Wang, M.-X.; Zhu, J.* Tuning the Reactivity of Isocyano Group: Synthesis of Imidazoles and Imidazoliums from Propargylamines and Isonitriles in the Presence of Multiple Catalysts. Angew. Chem. Int. Ed. 2015, 54, 1293-1297.
  4. Tong, S.#; Xu, Z.#; Mamboury, M.; Wang, Q.; Zhu, J.* Aqueous Titanium Trichloride-Promoted Reductive Cyclization of o-Nitrostyrenes to Indoles: Development and Application to the Synthesis of Rizatriptan and Aspidospermidine. Angew. Chem. Int. Ed. 2015, 54, 11809-11812.
  5. Tong, S.; Wang, Q.; Wang, M.-X.; Zhu, J.* Switchable [3+2] and [4+2] Heteroannulation of Primary Propargylamines with Isonitriles to Imidazoles and 1,6-Dihydropyrimidines: Catalyst Loading Enabled Reaction Divergence. Chem. Eur. J. 2016, 22, 8332-8338.
  6. Tong, S.; Zhao, S.; He, Q.; Wang, Q.; Wang, M.-X.; Zhu, J.* Fluorophores for Excited-state Intramolecular Proton Transfer by an Yttrium Triflate Catalyzed Reaction of Isocyanides with Thiocarboxylic Acids. Angew Chem. Int. Ed. 2017, 56, 6599-6603.
  7. Tong, S.#; Piemontesi, C.#; Wang, Q.; Wang, M.-X.; Zhu, J.* Silver-catalyzed Three-Component 1,1-Aminoacylation of Homopropargylamines: α-Additions for Both Terminal Alkynes and Isocyanide. Angew Chem. Int. Ed. 2017, 56, 7958-7962.
  8. Tong, S.; Limouni, A.; Wang, Q.; Wang, M.-X.; Zhu, J.* Catalytic Enantioselective Double Carbopalladation/C-H Functionalization with Statistical Amplification of Product Enantiopurity: A Convertible Linker Approach. Angew. Chem. Int. Ed. 2017, 56, 14192-14196.
  9. Tong, S.; Wang, Q.; Wang, M.-X.; Zhu, J.* Chiral Phosphoric Acid-catalyzed Enantioselective Three-component Mannich Reaction of Acyclic Ketones, Aldehydes and Anilines. Tetrahedron 2018, 74, 5143-5149.
  10. Yang, L.; Tong, S.; Wang, D.-X.; Huang, Z.-T.; Wang, M.-X.* Synthesis of Hydroxylated 3,4-Dihydropyridine-2-ones from Intramolecular Nucleophilic Addition Reaction of Oxiran-containing Tertiary Enamides. Synlett. 2011, 7, 927-930.
  11. Odabachian, Y.; Tong, S.; Wang, Q.; Wang, M.-X.; Zhu, J. Zinc Bromide Promoted Coupling of Isonitriles with Carboxylic Acids to form 2,4,5-Trisubstituted Oxazoles. Angew. Chem. Int. Ed. 2013, 52, 10878-10882.